![]() Some 60.5 per cent of COVID-19 deaths in Canada have been among people 80 and over, while Americans 85 and over account for 26 per cent of the U.S. COVID-19 death total. The difference in the most senior cohort is significant. ![]() citizens killed by COVID-19 since the pandemic began. The American flag is seen flying at half staff over the White House on Thursday to honour the one million U.S. In Canada, 92.7 per cent of the deaths tracked by Health Canada have occurred in people 60 and over. deaths, 75 per cent have occurred in people 65 and over, per the Centers for Disease Control. While the two countries don't break down demographic and age data in exactly the same way, some comparisons are informative. COVID-19 mortality in working-age population and Canada have seen a notable drop in life expectancy due to the pandemic.īut big differences between the countries can be seen in most age cohorts. Nearly 39,000 people have died in Canada.īoth the U.S. has experienced 302.93 deaths for every 100,000 people, per Johns Hopkins, a rate significantly higher than in Canada, with 104.30 deaths for every 100,000 people. ![]() has the highest official total of COVID-19 deaths in the world, although modelling on excess deaths published by both the World Health Organization and in medical journals and other publications has indicated other countries may have suffered greater levels of mortality but don't have as robust reporting mechanisms as the Americans. Just over two years into the pandemic, the U.S. Each leaving behind a family, a community and a nation forever changed because of this pandemic," said Biden. "One million empty chairs around the dinner table. President Joe Biden marked the solemn milestone with a statement on Thursday, expressing condolences to those in mourning. Numbers from the Johns Hopkins Coronavirus Resource Center and the Centers for Disease Control and Prevention vary slightly, but have the country poised to hit one million coronavirus deaths any day now. have surpassed one million, according to tallies compiled from Reuters and NBC News.
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![]() They are easy to turn into videos or interactive with google slides. These notes are great for in class or distance learning! They include clear instruction, key words & vocabulary, and a variety of examples. ![]() You can find a video where I work out these notes on my YouTube channel here. ![]() Completed Worked Out Notes that correspond with YouTube video.These notes get straight to the point of the skill being taught, which I have found is imperative for the attention span of teenagers! They are also a great tool for students to refer back to. Students and teachers love how easy these notes are to follow and understand. There are 6 examples included that provide a variety of practice. These notes go over writing the geometric sequence formula and using it to find the nth term. 1, 2, 4, 8, 16, Algebra Name Arithmetic and Geometric Sequences. Khan Academy is a nonprofit with the mission of providing a free, world-class education for anyone, anywhere. 2, 6, 18, 54, This is an increasing geometric sequence with a common ratio of 3. Learn for free about math, art, computer programming, economics, physics, chemistry, biology, medicine, finance, history, and more. This concise, to the point and no-prep geometric sequences lesson is a great way to teach & introduce how write the explicit formula for the nth term of a geometric sequence. Sometimes the terms of a geometric sequence get so large that you may need to express the terms in scientific notation rounded to the nearest tenth. Find the sixth term of a geometric sequence for which 2 288 and r 1 4. Write an equation for the nth term of the geometric sequence 3584, 896, 224. Continuing, the third term is: a3 ( a + d) + d. Since we get the next term by adding the common difference, the value of a2 is just: a2 a + d. For arithmetic sequences, the common difference is d, and the first term a1 is often referred to simply as 'a'. Textbook content produced by OpenStax is licensed under a Creative Commons Attribution License. Write an equation for the nth term of the geometric sequence 896, 448, 224. Since arithmetic and geometric sequences are so nice and regular, they have formulas. Use the information below to generate a citation. Then you must include on every digital page view the following attribution: If you are redistributing all or part of this book in a digital format, Then you must include on every physical page the following attribution: If you are redistributing all or part of this book in a print format, Want to cite, share, or modify this book? This book uses the Multiplying any term of the sequence by the common ratio 6 generates the subsequent term. The sequence below is an example of a geometric sequence because each term increases by a constant factor of 6. Each term of a geometric sequence increases or decreases by a constant factor called the common ratio. The yearly salary values described form a geometric sequence because they change by a constant factor each year. Great Think it might be an arithmetic or geometric sequence If the sequence has a common difference, its arithmetic. In this section, we will review sequences that grow in this way. When a salary increases by a constant rate each year, the salary grows by a constant factor. His salary will be $26,520 after one year $27,050.40 after two years $27,591.41 after three years and so on. His annual salary in any given year can be found by multiplying his salary from the previous year by 102%. He is promised a 2% cost of living increase each year. Suppose, for example, a recent college graduate finds a position as a sales manager earning an annual salary of $26,000. Many jobs offer an annual cost-of-living increase to keep salaries consistent with inflation. Use an explicit formula for a geometric sequence.Use a recursive formula for a geometric sequence.List the terms of a geometric sequence.Find the common ratio for a geometric sequence. ![]() Unlike a normal bank account, you do not have to pay any fees or charges for opening a PayPal account. One of the biggest advantages of opening a PayPal account is that is free. You can make any purchases or send money to family and friends in the U.S. If you are hesitant to provide your financial information every time you shop, that is not an issue. All your financial information is secure when you transfer money using a PayPal Account. It is an extremely safe platform for transaction. PayPal is a faster and simpler way to make recurring payments for your utility bills. You don’t have to pay anything to open a PayPal account. The key benefits of using a PayPal account are: PayPal is the faster and secure way of making payments online. It is not possible to directly use the funds in your PayPal account using a card. PayPal is simply a platform for fund transfer. The non-issuance of a PayPal debit card is also a limitation. You will have to use your existing debit card for transactions once the money from PayPal account is transferred. But remember that a separate PayPal debit card is not issued for account holders residing in India. You can then start making online purchases using debit cards. You need to transfer the money from the PayPal account to your savings account. This is in accordance to the restrictions set by the Reserve Bank of India (RBI).Īn Indian PayPal account holder, who receives money from another account, cannot use the remittance immediately to make any online purchases. Since PayPal is designed to facilitate international and cross border fund transfers, Indian customers cannot send or receive funds within India from customers who have PayPal accounts. SBI customers can open a PayPal account only after international usage is activated on their debit cards.Ī PayPal account has certain limitations: Since PayPal transactions are of international nature, this is an additional security feature provided by SBI. In case you have a SBI debit card, you must request your bank to activate international usage on their debit cards. You also must enter the purpose code (shopping, business, freelance). you need to provide your PAN card details, confirm you email ID and link the bank account you would be using to transfer money to your PayPal account. Step 7: After linking your debit card, you must complete your KYC compliance i.e. Step 6: You need to link your debit card by clicking on the "link card" tab. You will also have to enter your billing address Step 5: Next, you will be prompted to enter your debit card number, its expiry date and the CVV number mentioned on the flip side of the card. People who choose to have accounts as business persons or freelancers are simply required to enter their e-mail ID. You will be prompted to create a password to complete your Sign Up procedure. Step 4: If you choose the account as a shopper you will be redirected to a page where you provide your personal information such as your name and email address. Choose your type of account and proceed by clicking on the "next" tab. You need to choose whether you are opening the PayPal account as a shopper, a businessman or as a freelancer. Step 3: You will be redirected to a page where you select the type of account you would like to open. Step 2: Click on the "Sign Up" tab located on the top-right corner of the user interface screen. You can also download the PayPal mobile application from the Google Play Store or the Apple Store on your smartphone. ![]() Step 1: Visit the PayPal Home page by logging on to. You can your existing debit card to open your PayPal account: It is important to remember that you are not issued any separate PayPal debit card, if you are an account holder in India. Steps to open a PayPal account using debit card You are charged nominal transaction fees depending upon the payments made by you. A PayPal account can be opened free of charge. However, you need to check if the facility is provided by the online shopping website. It is also possible to use your PayPal account to make online payments. Once this is done, you can transfer the money to others. You can just register your bank account or debit card with your PayPal account. It also allows you to make purchases from international online stores, which includes eBay and Etsy. Simply use your PayPal account to transfer money to family and friends living abroad. ![]() PayPal is an international online payment system which allows you to send or request money online easily. ![]() I’m pretty experienced at finagling queen-size beds in and out of my tiny apartment these days, but I don’t enjoy the process. I’ve moved many mattresses to date-more than 10, in fact. While she’s not a back sleeper, she thinks its surface would lend it well to this sleep position, too. In our tester’s experience, it worked well for both sleep positions. It’s not uncomfortable for side sleepers, nor is it so soft that stomach sleepers will feel strain in their lumbar spine. The bed is pleasantly firm, but strikes a great balance. The Saatva mattress doesn’t come in a box-and it doesn’t feel like a mattress that would, either. The firm mattress feels like a traditional bed We believe Saatva is likely the closest premium ultra-luxury alternative (specifically their quality of materials, warranty & customer service, and price-to-performance) that you'll find both online or in stores.The Saatva Classic has unbeatable edge support. They're our #1 Best Mattress (out of the 397 brands we analyzed). Before you make a final buying decision, take a look at Saatva Classic's model. Based on the above facts, we don't comfortably recommend a Bioposture mattress. trial period, return, exchange & warranty policy, etc) to best accommodate your ‘test’ period. By extension, you want to select a brand that has friendly policies (i.e. The only true method to test the comfort & feel of a mattress is - you guessed it - in your bedroom. ‘Mattress comfort’ is personal preference that wildly changes between 2 people (you’d be surprised by how much it does differ). Our only goal is to make sure you have all the available information you need to make an informed decision. Our Bioposture review is not meant to make specific claims about how we 'think' you’ll feel on the mattress. Their overhead costs is higher than online stores which likely negatively impacts their decision to have friendly, forgiving policies (more friendly = more costly). This is a bigger headache if (and likely when) you want to return, exchange or experience a warranty event. Their policies are not as forgiving as other top online mattress brands (think Saatva or Puffy). However, there’s 1 major problem with brands & manufacturers like Bioposture (we don’t want to single them out). They also offer several mattress types, including: Moreover, people might love innerspring ‘bounciness' or latex ‘weightlessness'.īioposture builds & sells mattresses. Some people simply dislike the 'feel' memory foam has on their pressure points. It may seem like a no-brainer to ‘always’ select memory foam - since it's both great support and have great motion isolation. Some mattress types are better than others for support & isolation. Bioposture mattresses are built well (since they’re also their own manufacturer), so support is adequate. Motion transfer depends on how easily you & your partner become disturbed by small or large movements at night. Motion isolation, on the other hand, is more preferential. Everyone 'must' care about mattress support. Motion isolation describes how easily you or your partner are disturbed by movement when laying on a Bioposture mattress. Support refers to how well a Bioposture mattress can accommodate your sensitive pressure points. Support and motion isolation are 2 distinct but closely related characteristics of a mattress. The only true method to test comfort, feel & firmness is by physically laying on a Bioposture mattress (in the privacy of your own home). Bioposture is a brand that appears to be relatively comfortable mattress given what (1) our subjective testing has shown and (2) extensive reviews we've analyzed online. They're taught to present stories and marketing techniques instead of specific, accurate facts that allow consumers to make better comparisons. ![]() As a result, most mattress salespeople know almost nothing about the quality of the materials used in mattresses. Even worse, it's difficult (and sometimes virtually impossible) to easily compare specs or decipher confusing claims (and conflicting information). This is because most consumers don't understand what makes a high-quality mattress. Sadly, buying a mattress is usually a blind purchase. It's important to understand that buying a new mattress is one of the most critical purchases you can make in your life. Comfort, feel & firmness are extremely subjective and virtually impossible to comprehensively cover. Just check out these features:- 4X style strategy and city (re)building- Endless replayability with randomized cities and events- Survivors with individual skills, perks, relationships, andstories- Rival NPC forts with their own agendas, friendly orotherwise- Campaign Mode, a journey through cities of increasing size anddifficulty- Strategic fort defense and interactive attacks- Play in either real-time or turn-based mode- 5 skills: defense, leadership, scavenging, building,engineering- 10 resources and one-use items to find or craft- 30 missions: scavenge for food, kill zombies, farm, fish, trade,bartend.- 35 node research tree- 50 building types with unique uses and/or scavengeableresources- 70 types of equipment to find- 100 survivor perks: Melee Training, Green Thumb, LightSleeper.- 200,000 words of event text - enough to fill two novels And the dead are still out there wandering the streets,hungrier than ever.This sequel to the "unputdownable" Rebuild Mobile (aka Rebuild 2)is much MUCH bigger. ![]() As you expand your fort to new buildings, you'll decidebetween farms or fortifications, housing or hospitals, and maketough decisions to fend off raiders, illness, starvation, andmadness. It's a thoughtful game that'll make you fond ofyour survivors before you send them to their deaths for the greatergood. Now you must gather them up and restorecivilization to a ruined city, one building at a time.Rebuild 3 is a strategy sim game with a good helping of narrativeand dark humor. ![]() ![]() It's been a few years since the zombpocalypseturned the world's cities into graveyards and sent the fewsurvivors into hiding. Only use Apple’s lightning or USB cable to connect the iPhone to the PC. If you are not seeing the computer name on the Screen Mirroring list of nearby casting devices, then make sure you have connected your iPhone and computer properly. Using Reflector to wireless display iPhone on MAC is just as easy as using other simple screen-mirroring apps. Screen Mirroring Cannot Discover the Computer. The quality will be of high definition on both the Reflector app as well as LonelyScreen. Reflector 2 takes direct advantage of Apple’s AirPlay technology to let you cast your iPhone and iPad’s screen to any Android device, including Fire TV and Fire Stick. More info about AirPlayMirror Reflector 2 AirPlay Receiver. To remove that, you need to buy the full version of the app.Īlso, the screen will be cast vertically with the backdrop of an iPhone. Connect the devices, then pick content on your iOS hardware and start mirroring. The trial version of Reflector will have a watermark on it. When you wish to end the casting, do it by tapping on Screen Mirroring from iPhone control enter. Now, the screen of the iPhone will start to cast on the screen of the Windows 11 computer.Now, the Reflector app, which is open on your computer, will show a 4-digit code.You will be asked to enter the AirPlay Code on your iPhone.The laptop/computer name will show up as the available device for screencasting. ![]() They offer limited free usage, after which you have to purchase these apps to use them and unlock other features they offer. The apps that I will show you in this guide are LonelyScreen and Reflector. Using LonelyScreen and Reflector 4 to Cast iOS to Windows 11 While I could project my Android phone easily on Windows 11, the same could not be done with my iPhone. I tried with my smartphones, to be precise. When I say any smartphone, the feature is limited to Windows and Android smartphones. Then you can connect any smartphone to your PC and cast the phone’s screen on Windows 11. There is a feature called Projecting to This PC on Windows 11, which you have to enable along with the wireless display support. Windows OS does support free screencasting of intelligent devices. Which ScreenCasting App for iPhone is Better?Ĭan You Mirror iPhone to Windows 11 Without Any App? Reflector lets you mirror your iPhone and iPad display to a Mac or PC.Screen Mirroring Cannot Discover the Computer.Reflector Director allows you to step away from your computer while still controlling how your audience views the devices that are connected to Reflector 4. ![]()
![]() “ PEN15” premièred in 2019 and became a cult hit. Konkle, staying in character, said, “What? I’m glad you’re enjoying life.” O.K., I need that.” (To each other, Maya and Anna are Mai and Na.) Erskine turned to look at Konkle, but then she broke again. She took a breath and regained her composure. Then she got the giggles and had to stop. Dippin’ Dots! Dippin’ Dots!” Erskine exclaimed suddenly, eying a station offering ice-cream pellets. “No, I mean, like, on Earth,” Konkle said. “I dunno, it’s Becca’s bat mitzvah,” Erskine replied. “Who are these people, and why are they here?” Konkle muttered. “Oh, my God, this party is amazing,” Erskine said. Konkle, as Anna (tall, laconic, slouched), stood behind her, glowering, in the throes of a fatalistic mood brought on, earlier in the episode, by a lesson on the Holocaust. The women took their places, in a buffet line, and the episode’s director, Dan Longino, called “Action.” Erskine, as Maya (short, hyperactive, impish), jiggled her body to the beat. ![]() ![]() Teen-age extras and white-haired elders in yarmulkes checked out a station for making airbrushed T-shirts. playing the 1998 techno-pop song “Blue (Da Ba Dee)” as a triad of sequin-clad hype dancers did the Running Man on a laminate dance floor. A camera crew was filming B-roll footage of a d.j. At about 11 A.M., they entered a banquet hall inside the Pacific Palms, where the party had been staged in period-specific teenybopper style. The women were preparing to shoot an episode from the show’s third season in which their younger avatars attend a popular girl’s bat-mitzvah party at a country club. Their junior-high burlesque is a sight gag as well as the heart of the series more literally than most teen pariahs, Maya and Anna have trouble fitting in. Erskine and Konkle don’t convincingly pass among them, but that is the point. It’s painful, but so is being thirteen.Īll other middle schoolers on “ PEN15” are played by adolescents: the popular girls, the other outcasts, the unrequited crushes. ![]() (“My orthodontist made a mistake,” she said.) The mouthpiece cuts into Konkle’s gums and makes it nearly impossible for her to eat or drink. The women then moved to an adjacent costume trailer to complete their “ PEN15” looks: for Maya, a black bowl-cut wig that resembles a giant porcini mushroom, similar to Erskine’s haircut in fifth grade for Anna, a set of protruding pop-in braces that mimic the ones Konkle had to wear-twice. Beside her, a hair stylist twisted strands of Konkle’s fine blond hair around the neck of a tiny curling iron, creating bouncy corkscrews. “I was made fun of for being hairy-I had a deep insecurity about that,” Erskine told me. In the makeup trailer, Erskine sat in front of a vanity mirror as a stylist wearing a face shield used a felt-tip pen to paint hundreds of tiny strokes onto her upper lip, creating the illusion of a faint mustache. The women, who are both thirty-four, are co-creators and co-stars of “ PEN15,” a Hulu series in which they play versions of themselves as teen-agers, the thirteen-year-old best friends and misfits Maya Ishii-Peters and Anna Kone. It was a sizzling August morning in 2021, but inside a hair-and-makeup trailer parked at the Pacific Palms Resort, an hour east of Hollywood, Maya Erskine and Anna Konkle were returning to the year 2000. Moreover, GAPDH expression is regulated by transcription factors which are frequently altered in cancer such as HIF-1α, p53 or AP-1. In fact, GAPDH is one of the multifaceted glycolytic enzymes that contributes to cell survival and resistance to cell death, becoming a promising biomarker in cancer research. GAPDH is constituted by four identical subunits of 37 kDa and has binding sequences for coenzymes NAD+ and NADH and for nucleic acids. GAPDH catalyses the phosphorylation and oxidation of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate coupled with the reduction of NAD+ to NADH. This fact advises against its widely extended use as a housekeeping gene. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH, EC 1.2.1.12) is an essential regulator of glycolysis ubiquitously overexpressed in 21 cancer classes, being one of the three glycolytic genes overexpressed in colorectal cancer, along with enolase and pyruvate kinase. However, further studies are required to identify new biomarkers to predict CRC outcome, help to understand its evolution and find the most suitable treatment. Cancer staging systems help oncologists to evaluate disease prognosis, treatment suitability and the possibilities of patients to be enrolled in specific clinical trials, contributing to fight CRC. The American Joint Committee on Cancer (AJCC) TNM staging system establishes four different stages of tumour progression (I to IV) depending on the primary tumour extent (T), the regional lymph node involvement (N) and the absence or presence of distant metastasis (M). Fortunately, systematic risk population screening programmes facilitate early detection and treatment reducing its incidence and mortality rate. In addition, cancer cells from the primary site can have the ability to invade other tissues resulting in metastasis, the major cause of death from cancer.Ĭolorectal cancer (CRC) is a global leading cause of cancer-related mortality being the third most common cancer in men and the second in women worldwide. Cancer is a prevalent multifactorial disease characterised by loss of physiological control and malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. Multifactorial diseases result from the interaction between genetic susceptibility and environmental factors and do not exhibit a clear hereditary pattern, which causes difficulties in their risk evaluation, diagnosis and treatment. Studying the role of GAPDH in malignant transformation can shed new light on the understanding of tumour onset and lead to the design of more efficient personalised therapies. These results were reinforced by those obtained at mRNA level. Overexpression of GAPDH is positively associated with early stage tumours without regional lymph node and distant metastases involved. Groups were compared using Kruskal-Wallis tests. Probability of patient survival and disease-free survival were analysed by the univariate product-limit method of Kaplan-Meier. ![]() Gene expression profiling was performed using Affymetrix microarrays. Staining quantification was performed by computational image analysis, and correlations between GAPDH expression and tumour progression stage were assessed. GAPDH expression was immunohistochemically analysed in tumour tissues from 62 colorectal cancer (CRC) patients, and validated at mRNA level in an independent dataset comprising 98 paired stage II CRC and normal samples. Given the pivotal role of GAPDH in tumour metabolism, our aim was to correlate its protein expression with tumour staging and prognosis of colorectal cancer. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential regulator of glycolysis used as a housekeeping marker for gene/protein normalisation. |
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